Natural Sugar

Natural sugars are unknown for most of the general population. When sugar comes to mind, table sugar, or sucrose, is what normal people think of. The refined sugar should be avoided entirely but it's still better than artificial sweeteners or high fructose corn syrup.

In actuality, there are hundreds of sugars that occur naturally in nature and several of them now appear on our supermarket shelves. They are great, healthier alternatives to the artificial, refined sweeteners.

Sugars are the most abundant biological molecules in nature. While most people think of sugars as something to make our food and drinks sweet, many natural sugars or dietary sugars are indespensible to all life.

Functions of Natural Sugars

Some of the more vital functions that natural sugars and starches (carbohydrates) perform are storing and transporting energy and providing the building materials to construct the scaffolding that forms the supporting structure of cells.

They also play major roles in the working of our immune system, fertilization in the reproductive system, clotting of blood as well as determining our blood type.

Even the fundamental ‘codes’ of life (DNA and RNA) are carbohydrate-based chains of recurring molecules called polymers.

By now most people know about genes and our efforts to classify all the genes of the body into a collection called the genome.

Functional Glycomics

Likewise, there is an ongoing effort in many scientific circles to map the sugar chains into a glycome, analagous to the genome.

This body of science has become known as Glycomics with an attendant area of study called glycobiology, or the study of the role of sugars in life.

Many of the roles that nature has assigned to natural sugars are truly awesome. In our bodies, nature uses certain sugars combined with a protein backbone, called a glycoprotein, to perform guard duty.

As sentrys, their job is to recognize suspect cells such as mutations, bacteria, viruses, toxins and mark them for destruction by our immune system.

To say it another way, carbohydrate structures on the cell surface enable the cell to differentiate between resident cells that belong and illegal alien cells that don't.

In scientific language, a researcher might say something to the effect that "it is carbohydrate structures that act as signal or recognition markers to mediate cell-to-cell recognition, cell-to-cell adhesion and molecular targeting".

Interestingly, scientists have noted that in the presence of inflammatory diseases, infections and the development of malignant cancers, changes occur in the glycoforms, the carbohydrate structure on the cell surface.

Introduction to Glycobiology

The changes affect the physical, chemical and biological properties of the cell surface glycoproteins which in turn have dramatic effects on all the functions of the cell.

Glycoforms were mentioned in the preceeding paragraph and another name for them is glycoconjugates. They are simply a protein or lipid (fat) with various bioactive sugars attached.

Most such glycoconjugates have molecules of the sugars mannose, fucose, xylose or five others attached.

Cellular Manipulation of Natural Sugars

The construction of glycoconjugates occurs deep within the cell in an internal structure known as the endoplasmic reticulum or ER for short.

The ER is the cellular assembly line for glycoconjugates and once the structure is built it is shuttled off to another internal structure known as the golgi appartus. The golgi appartus is the cells postal system or distribution system.

The completed glycoforms (glycoconjugates) then penetrate the cellular membrane and take the appearance of a forest of hairs or cilli on the cell surface.

Here the glycoforms communicate with other cells and the transmitted messages can alter the biosynthesis, stability, localization, trafficking, action, and turnover of the molecules comprising the total organism. These processes are also covered in great detail in the glyconnutrient pages linked above.

For this reason, glycobiology and carbohydrate chemistry have gained increasing importance in modern biotechnology.

Many major universities have established huge departments devoted to glycobiology and so far, this is the source of most discoveries in the roles of natural sugars on life.

Several pharmaceutical firms are now devoting a considerable amount of time and money to studying sugars in the hope of finding ways to incorporated their characteristics into new sugar-based drugs; patentable of course.

The practical application of such research into how biological interactions and functions are affected by glycans (sugar structures) will hopefully lead to a way to manipulate them in the human body.

It is encouraging that several human diseases are characterized by changes in glycan biosynthesis which is a driving force in the search for new tools in diagnostics and/or therapeutic applications.

What is Glycan?

"Glycan" may be a new word to many readers, so let's clarify that glycans are composed of multiple linked sugars and are essential structural components of living cells and a source of energy for animals.

The diverse biological functions attributed to glycans can be grouped into two general classes:

(1) structural modulation

(2 ) recognition.

As modulators, the glycans impart intelligence to the molecule to which they are attached and thus facilitate changes to the molecule. In the recognition role, glycans are recognized by carbohydrate-binding proteins called lectins.

Glycans are widely distributed in nature and, as previously mentioned, their study has become one of the more rapidly growing fields in the biomedical sciences, with relevance to basic research, biomedicine, and biotechnology.

The field ranges from the chemistry of carbohydrates and the enzymology of glycan-modifying proteins to the functions of glycans in complex biological systems, and their manipulation by a variety of techniques.

Glycosylation

The term that describes how newly synthesized proteins originating from the ER (endoplasmic reticulum) are modified with sugar chains is called "glycosylation".

Most glycosylation reactions utilize activated forms of monosaccharides that are catalyzed, or enabled, by enzymes called glycosyltransferases. It appears that most observed changes in sugar structures in the body are enabled by enzymes.

A huge amount of research has gone into understanding the mechanisms of glycosylation and it is clear that a variety of factors determine the final outcome of glycosylation reactions.

Like all components of living cells, glycans are constantly being created and broken down (degraded). Enzymes take care of the sugar chain degradation by cutting the chain at either end.

Then it is possible to remove the cut piece and re-attach a different section of chain without disturbing the underlying main body of the structure.

Sugar structures are almost never straight-line chains but rather have numerous branching chains, like limbs of a tree.

It happens that defects in the construction, or biosynthesis, of the sugar structure often produce a variety of mutant glycoforms which have provided a large body of knowledge into the pathways that biosynthesis can take.

So it is no wonder that many companies are trying to learn how to create pharmaceuticals based on the science of glycobiology. Will they be successful? Probably, but it seems like a waste of energy since the bioactive natural sugars are readily available in whole food and supplement forms.

Just take them and let the cells internal machinery do the work; but then again, you can't patent natural sugars or a natural function of our cells.

In addition, whatever sugar-based drugs that the pharmaceutical companies come up with is sure to be at least ten years away and will be very expensive.

This post was published on November 15, 2019 1:36 pm